Trimerlizin II
(Preusmjereno sa stranice H2-proteinaza)
| Trimerlizin II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.53 | ||||||||
| CAS broj | 151125-15-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trimerlizin II (EC 3.4.24.53, Trimeresurus metaloendopeptidaza II, proteinaza H2, H2-proteinaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Asn3-Gln, His10-Leu i Ala14-Leu u lancu insulina B, i veze Z-Gly-Pro-Leu-Gly-Pro malim molekulima koji su supstrati mikrobne kolagenaze
Ova nehemoragična endopeptidaza je prisutna u venumu zmije Trimeresurus flavoviridis.
Reference[uredi | uredi kod]
- ↑ Takahashi, T. and Ohsaka, A. (1970). „Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity”. Biochim. Biophys. Acta 198: 293-307. PMID 4984550.
- ↑ Takeya, H., Arakawa, M., Miyata, T., Iwanaga, S. and Omori-Satoh, T. (1989). „Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis”. J. Biochem. (Tokyo) 106: 151-157. PMID 2777746.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.