Glimepirid

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Glimepirid
(IUPAC) ime
3-ethil-4-metil-N- {2-[4-({[(4-metilcikloheksil)karbamoil]amino}sulfonil)fenil]etil2-okso-2,5-dihidro-1H-pirol-1-karboksamid
Klinički podaci
Robne marke Amarel, Amaryl, Endial, Novo-glimepiride
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 93479-97-1
ATC kod A10BB12
PubChem[1][2] 3476
DrugBank DB00222
ChemSpider[3] 3357
KEGG[4] C07669 YesY
ChEMBL[5] CHEMBL5383 YesY
Hemijski podaci
Formula C24H34N4O5S 
Mol. masa 490.616
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 207 °C (405 °F)
Farmakokinetički podaci
Poluvreme eliminacije 5 sati
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Glimepirid je bila prva sulfonil ureja treće generacije sa primenom kao antidijabetesni lek. Ovaj lek je veoma potentan i ima dugo vreme trajanja.[6][7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  7. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets" 36 (Database issue). pp. D901–6. PMID 18048412. 

Spoljašnje veze[uredi - уреди | uredi izvor]

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