Germakren A alkohol dehidrogenaza
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| Germakren A alkohol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.314 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Germakren A alkohol dehidrogenaza (EC 1.1.1.314, germakren A alkoholna dehidrogenaza) je enzim sa sistematskim imenom germakra-1(10),4,11(13)-trien-12-ol:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- germakra-1(10),4,11(13)-trien-12-ol + 2 NADP+ +H2O germakra-1(10),4,11(13)-trien-12-oat + 2 NADPH + 3 H+ (sveukupna reakcija)
- (1a) germakra-1(10),4,11(13)-trien-12-ol + NADP+ germakra-1(10),4,11(13)-trien-12-al + NADPH + H+
- (1b) germakra-1(10),4,11(13)-trien-12-al + NADP+ +H2O germakra-1(10),4,11(13)-trin-12-oat + NADPH + 2 H+
Kod Lactuca sativa ovaj enzim je mutifunkcionalan. On takođe deluje kao EC 1.14.13.123, germakren A hidroksilaza.
Reference[uredi | uredi kod]
- ↑ de Kraker, J.W., Franssen, M.C., Dalm, M.C., de Groot, A. and Bouwmeester, H.J. (2001). „Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene A hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis”. Plant Physiol. 125: 1930-1940. PMID 11299372.
- ↑ Nguyen, D.T., Gopfert, J.C., Ikezawa, N., Macnevin, G., Kathiresan, M., Conrad, J., Spring, O. and Ro, D.K. (2010). „Biochemical conservation and evolution of germacrene A oxidase in asteraceae”. J. Biol. Chem. 285: 16588-16598. PMID 20351109.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.