Gama-terpinenska sintaza
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| Gama-terpinenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.114 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gama-terpinenska sintaza (EC 4.2.3.114, OvTPS2, ClcTS) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira gama-terpinen).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat gama-terpinen + difosfat
Enzim je izolovan iz Thymus vulgaris, Citrus limon (limuna), Citrus unshiu i Origanum vulgare (oregana).
Reference[uredi | uredi kod]
- ↑ Alonso, W.R. and Croteau, R. (1991). „Purification and characterization of the monoterpene cyclase γ-terpinene synthase from Thymus vulgaris”. Arch. Biochem. Biophys. 286: 511-517. PMID 1897973.
- ↑ LaFever, R.E. and Croteau, R. (1993). „Hydride shifts in the biosynthesis of the p-menthane monoterpenes α-terpinene, γ-terpinene, and β-phellandrene”. Arch. Biochem. Biophys. 301: 361-366. PMID 8460944.
- ↑ Lücker, J., El Tamer, M.K., Schwab, W., Verstappen, F.W., van der Plas, L.H., Bouwmeester, H.J. and Verhoeven, H.A. (2000). „Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases”. Eur. J. Biochem. 269: 3160-3171. PMID 12084056.
- ↑ Suzuki, Y., Sakai, H., Shimada, T., Omura, M., Kumazawa, S. and Nakayama, T. (2004). „Characterization of γ-terpinene synthase from Citrus unshiu (Satsuma mandarin)”. Biofactors 21: 79-82. PMID 15630174.
- ↑ Crocoll, C., Asbach, J., Novak, J., Gershenzon, J. and Degenhardt, J. (2010). „Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis”. Plant Mol. Biol. 73: 587-603. PMID 20419468.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.