Gama-D-glutamil-meso-diaminopimelatna peptidaza

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Gama-D-glutamil-meso-diaminopimelatna peptidaza
Identifikatori
EC broj 3.4.19.11
CAS broj 62572-28-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Gama-D-glutamil-meso-diaminopimelatna peptidaza (EC 3.4.19.11, endopeptidaza I, gama-D-glutamildiaminopimelatna endopeptidaza, gama-D-glutamil-L-meso-diaminopimelatna peptidoglikanska hidrolaza, gama-glutamil-L-meso-diaminopimelilna endopeptidaza, gama-D-glutamil-meso-diaminopimelatna endopeptidaza, gama-D-glutamil-meso-diaminopimelinska peptidoglikanska hidrolaza, gama-D-glutamil-meso-diaminopimelinska endopeptidaza, gama-D-glutamil-meso-D-aminopimelinska endopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

hidroliza gama-D-glutamilnih veza do L-terminusa (pozicije 7) meso-diaminopimelinske kiselina (meso-A2pm) in 7-(L-Ala-gama-D-Glu)-meso-A2pm i 7-(L-Ala-gama-D-Glu)-7-(D-Ala)-meso-A2pm. Neophodno je da D-terminalne amino i karboksi grupe meso-A2pm nisu supstituisane

Ova metalopeptidaza je izolovana iz bakterije Bacillus sphaericus.

Reference[uredi - уреди | uredi izvor]

  1. Arminjon, F., Guinand, M., Vacheron, M.-J. and Michel, G. (1977). "Specificity profiles of the membrane-bound γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602". Eur. J. Biochem. 73: 557–565. PMID 849747. 
  2. Garnier, M., Vacheron, M.-J., Guinard, M. and Michel, G. (1985). "Purification and partial characterization of the extracellular γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602". Eur. J. Biochem. 148: 539–543. PMID 3922755. 
  3. Hourdou, M.-L., Guinand, M., Vacheron, M.-J., Michel, G., Denoroy, L., Duez, C., Englebert, S., Joris, B., Weber, G. and Ghuysen, J.-M. (1993). "Characterization of the sporulation-related γ-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein". Biochem. J. 292: 563–570. PMID 8503890. 

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