Fosfoglicerol geranilgeraniltransferaza
(Preusmjereno sa stranice GGGP sintaza)
| Fosfoglicerol geranilgeraniltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.41 | ||||||||
| CAS broj | 124650-69-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfoglicerol geranilgeraniltransferaza (EC 2.5.1.41, glicerol fosfat geranilgeraniltransferaza, geranilgeranil-transferaza, preniltransferaza, (S)-3-O-geranilgeranilgliceril fosfat sintaza, (S)-geranilgeranilgliceril fosfat sintaza, GGGP sintaza, (S)-GGGP sintaza, GGGPS, geranilgeranil difosfat:sn-gliceril fosfat geranilgeraniltransferaza, geranilgeranil difosfat:sn-glicerol-1-fosfat geranilgeraniltransferaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:sn-glicerol-1-fosfat geranilgeraniltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranilgeranil difosfat + sn-glicerol 1-fosfat difosfat + sn-3-O-(geranilgeranil)glicerol 1-fosfat
Ovaj citosolni enzim katalizuje prvi korak biosinteze membranskog dietarskog lipida kod arhabakterija. Za njegovo maksimalno dejstvo je neophodan Mg2+.
Reference[uredi | uredi kod]
- ↑ Zhang, D.-L., Daniels, L. and Poulter, C.D. (1990). „Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction”. J. Am. Chem. Soc. 112: 1264-1265.
- ↑ Chen, A., Zhang, D. and Poulter, C.D. (1993). „(S)-Geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis”. J. Biol. Chem. 268: 21701-21705. PMID 8408023.
- ↑ Nemoto, N., Oshima, T. and Yamagishi, A. (2003). „Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum”. J. Biochem. 133: 651-657. PMID 12801917.
- ↑ Payandeh, J., Fujihashi, M., Gillon, W. and Pai, E.F. (2006). „The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme”. J. Biol. Chem. 281: 6070-6078. PMID 16377641.
- ↑ Morii, H., Nishihara, M. and Koga, Y. (2000). „CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus”. J. Biol. Chem. 275: 36568-36574. PMID 10960477.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.