GDP-4-dehidro-6-dezoksi-D-manoza reduktaza
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| GDP-4-dehidro-6-dezoksi-D-manoza reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.281 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GDP-4-dehidro-6-dezoksi-D-manoza reduktaza (EC 1.1.1.281, GDP-4-keto-6-dezoksi-D-manoza reduktaza (ambiguous), GDP-6-dezoksi-D-likso-4-heksuloza reduktaza, Rmd, GDP-6-dezoksi-D-manoza:NAD(P)+ 4-oksidoreduktaza (formira D-ramnoza)) je enzim sa sistematskim imenom GDP-6-dezoksi-alfa-D-manoza:NAD(P)+ 4-oksidoreduktaza (formira D-ramnozu).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-6-dezoksi-alfa-D-manoza + NAD(P)+ GDP-4-dehidro-6-dezoksi-alfa-D-manoza + NAD(P)H + H+
Ovaj enzim se razlikuje od EC 1.1.1.187, GDP-4-dehidro-D-ramnoza reduktaze, po tome što je jedini produkt GDP-alfa-D-ramnoza (GDP-6-dezoksi-alfa-D-manoza). D-ramnoza je konstituent lipopolisaharida Gram-negativnih biljnih i humanih patogenih bakterija.
Reference[uredi | uredi kod]
- ↑ Kneidinger, B., Graninger, M., Adam, G., Puchberger, M., Kosma, P., Zayni, S. and Messner, P. (2001). „Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T”. J. Biol. Chem. 276: 5577-5583. PMID 11096116.
- ↑ Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Mattila, P. and Renkonen, R. (2002). „Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose”. Eur. J. Biochem. 269: 593-601. PMID 11856318.
Literatura[uredi | uredi kod]
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- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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