Fosfoetanolamin/fosfoholinska fosfataza
(Preusmjereno sa stranice Fosfoetanolamin/fosfoholin fosfataza)
| Fosfoetanolamin/fosfoholinska fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.75 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfoetanolamin/fosfoholinska fosfataza (EC 3.1.3.75, PHOSPHO1, 3X11A) je enzim sa sistematskim imenom fosfoetanolamin fosfohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) O-fosfoeetanolamin + H2O etanolamin + fosfat
- (2) fosfoholin + H2O holin + fosfat
Za rad ovog enzim je neophodan Mg2+.
Reference[uredi | uredi kod]
- ↑ Houston, B., Seawright, E., Jefferies, D., Hoogland, E., Lester, D., Whitehead, C. and Farquharson, C. (1999). „Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes”. Biochim. Biophys. Acta 1448: 500-506. PMID 9990301.
- ↑ Stewart, A.J., Schmid, R., Blindauer, C.A., Paisey, S.J. and Farquharson, C. (2003). „Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily”. Protein Eng. 16: 889-895. PMID 14983068.
- ↑ Roberts, S.J., Stewart, A.J., Sadler, P.J. and Farquharson, C. (2004). „Human PHOSPHO1 displays high specific phosphoethanolamine and phosphocholine phosphatase activities”. Biochem. J. 382: 59-65. PMID 15175005.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.