Farnezilcistein lijaza
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| Farnezilcistein lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.3.6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Farnezilcistein lijaza (EC 1.8.3.6, FC lijaza, FCLY) je enzim sa sistematskim imenom S-(2E,6E)-farnezil-L-cistein oksidaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-(2E,6E)-farnezil-L-cistein + O2 +H2O (2E,6E)-farnesal + L-cistein +H2O2
Ovaj enzim je flavoprotein (FAD). U kontrastu sa sisarskim enzimom EC 1.8.3.5 (prenilcisteinskom oksidazom) farnezilcisteinska lijaza iz Arabidopsis je specifična za S-farnezil-L-cistein.
Reference[uredi | uredi kod]
- ↑ Huizinga, D.H., Denton, R., Koehler, K.G., Tomasello, A., Wood, L., Sen, S.E. and Crowell, D.N. (2010). „Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis”. Mol Plant 3: 143-155. PMID 19969520.
- ↑ Crowell, D.N., Huizinga, D.H., Deem, A.K., Trobaugh, C., Denton, R. and Sen, S.E. (2007). „Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine”. Plant J. 50: 839-847. PMID 17425716.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.