L-metionin (S)-S-oksid reduktaza
(Preusmjereno sa stranice FSMsr)
| L-metionin (S)-S-oksid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.4.13 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-metionin (S)-S-oksid reduktaza (EC 1.8.4.13, fSMsr, metil sulfoksid reduktaza I i II, acetilmetionin sulfoksidna reduktaza, metionin sulfoksidna reduktaza, L-metionin:oksidovani-tioredoksin S-oksidoreduktaza, metionin-S-oksidna reduktaza, free-metionin (S)-S-oksidna reduktaza) je enzim sa sistematskim imenom L-metionin:tioredoksin-disulfid S-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-metionin + tioredoksin disulfid +H2O L-metionin (S)-S-oksid + tioredoksin
Za rad ovog enzima je neophodan NADPH. Reakcija se odvija u reverznom smeru.
Reference[uredi | uredi kod]
- ↑ Black, S., Harte, E.M., Hudson, B. and Wartofsky, L. (1960). „A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides”. J. Biol. Chem. 235: 2910-2916.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1979). „Reduction of methionine sulfoxide to methionine by Escherichia coli”. J. Bacteriol. 139: 161-164. PMID 37234.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1980). „The purification of methionine sulfoxide reductase from Escherichia coli”. Anal. Biochem. 102: 393-398. PMID 6999943.
- ↑ Weissbach, H., Resnick, L. and Brot, N. (2005). „Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage”. Biochim. Biophys. Acta 1703: 203-212. PMID 15680228.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.