Enoksacin

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Enoksacin
(IUPAC) ime
1-etil-6-fluoro-4-okso-7-(piperazin-1-il)-1,4-dihidro-1,8-naftiridin-3-karboksilna kiselina
Klinički podaci
AHFS/Drugs.com Monografija
MedlinePlus a601013
Identifikatori
CAS broj 74011-58-8
ATC kod J01MA04
PubChem[1][2] 3229
DrugBank DB00467
ChemSpider[3] 3116
UNII 325OGW249P YesY
KEGG[4] D00310 YesY
ChEBI CHEBI:157175 YesY
ChEMBL[5] CHEMBL826 YesY
Hemijski podaci
Formula C15H17FN4O3 
Mol. masa 320,319 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Enoksacin (Almitil, Bactidan, Bactidron, Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark, Penetrex, Gyramid, Vinone) je oralni fluorohinolonski antibakterijski agens širokog spektra koji se koristi u tretmanu infekcija urinarnog trakta i gonoreja. Insomnija je česta nuspojava pri upotrebi ovog leka.[6][7]

Nedavno je pokazano da ova supstanca može da inhibira kancer.[8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V, ed. "Quinolones for uncomplicated acute cystitis in women". Cochrane Database Syst Rev 3: CD003597. PMID 16856014. doi:10.1002/14651858.CD003597.pub2. 
  7. Mogabgab, WJ. (Dec 1991). "Recent developments in the treatment of sexually transmitted diseases". Am J Med 91 (6A): 140S–144S. PMID 1767802. doi:10.1016/0002-9343(91)90327-T.  Check date values in: |date= (help)
  8. Sonia Melo, Alberto Villanueva, Catia Moutinho, Veronica Davalos, Riccardo Spizzo, Cristina Ivan, Simona Rossi, Fernando Setien, Oriol Casanovas, Laia Simo-Riudalbas, Javier Carmona, Jordi Carrere, August Vidal, Alvaro Aytes, Sara Puertas, Santiago Ropero, Raghu Kalluri, Carlo M. Croce, George A. Calin, Manel Estellera (2011). "Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing". PNAS. doi:10.1073/pnas.1014720108. 

Literatura[uredi - уреди | uredi izvor]

  • Patel, SS; Spencer, CM (January 1996). "Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections". Drugs 51 (1): 137–60. PMID 8741236.  .

Spoljašnje veze[uredi - уреди | uredi izvor]

Star of life.svg Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).