Saharopepsin
(Preusmjereno sa stranice EC 3.4.23.25)
| Saharopepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.25 | ||||||||
| CAS broj | 37228-80-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Saharopepsin (EC 3.4.23.25, kvašćana endopeptidaza A, Saccharomyces aspartinska proteinaza, aspartinska proteinaza yscA, proteinaza A, proteinaza yscA, kvašćana proteinaza A, Saccharomyces cerevisiae aspartinska proteinaza A, kvašćana proteinaza A, PRA) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičnošću za peptidne veze. Razlaže se -Leu-Leu-Val-Tyr veza u sintetičnim supstratime. Ne dolazi do reakcije na estrima Tyr ili Arg
Ovaj enzim je prisutan u vakuolama pekarskog kvasca (Saccharomyces cerevisiae).
Reference[uredi | uredi kod]
- ↑ Hata, T., Hayashi, R. and Dot, E. (1967). „Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C”. Agric. Biol. Chem. 31: 357-367.
- ↑ Meussdoerffer, F., Tortora, P. and Holzer, H. (1980). „Purification and properties of proteinase A from yeast”. J. Biol. Chem. 255: 12087-12093. PMID 7002931.
- ↑ Ammerer, G., Hunter, C.P., Rothman, J.H., Saari, G.C., Valls, L.A. and Stevens, T.H. (1987). „PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors”. Mol. Cell. Biol. 6: 2490-2499. PMID 3023936.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.