U-plasminogeni aktivator

Iz Wikipedije, slobodne enciklopedije
(Preusmjereno sa EC 3.4.21.73)
U-plasminogeni aktivator
Identifikatori
EC broj 3.4.21.73
CAS broj 9039-53-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

U-plasminogeni aktivator (EC 3.4.21.73, urokinaza, urinarni plazminogenski aktivator, ćelijski plazminogenski aktivator, urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, urokinazni plazminogenski aktivator, uPA, u-PA, abokinaza, urinarna esteraza A) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Specifično razlaganje Arg-Val veze u plasminogenu čime se formira plazmin

Ovaj enzim se formira iz neaktivnog prekursora posredstvom plazmina ili kalikreina plazme.

Reference[uredi - уреди | uredi izvor]

  1. Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L. (1981). "Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates". Methods Enzymol. 80: 341–361. PMID 6210826. 
  2. Loskutoff, D.J. and Schleef, R.R. (1988). "Plasminogen activators and their inhibitors". Methods Enzymol. 163: 293–302. PMID 3148826. 
  3. Saksela, O. and Rifkin, D.B. (1988). "Cell-associated plasminogen activation: regulation and physiological functions". Annu. Rev. Cell Biol. 4: 93–126. PMID 3143380. 
  4. Collen, D., Lijnen, H. R. and Verstraete, M. (1990). "The fibrinolytic system and its disorders". u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -. 
  5. Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D. (1990). "Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Glu)". J. Biol. Chem. 265: 5232–5236. PMID 1969415. 

Literatura[uredi - уреди | uredi izvor]

  • Collen, D., Lijnen, H. R. and Verstraete, M. (1990). "The fibrinolytic system and its disorders". u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -. 

Spoljašnje veze[uredi - уреди | uredi izvor]