Naringenin-halkon sintaza
(Preusmjereno sa stranice EC 2.3.1.74)
| Naringenin-halkon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.74 | ||||||||
| CAS broj | 56803-04-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Naringenin-halkon sintaza (EC 2.3.1.74, halkonska sintaza, flavanonska sintaza, 6'-dezoksihalkonska sintaza, DOCS, CHS) je enzim sa sistematskim imenom malonil-KoA:4-kumaroil-KoA maloniltransferaza (ciklizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 malonil-KoA + 4-kumaroil-KoA 4 KoA + naringenin halkon + 3 CO2
U prisustvu NADH i reduktaza se formira 6'-dezoksihalkon.
Reference[uredi | uredi kod]
- ↑ Ayabe, S.-I., Udagawa, A. and Furuya, T. (1988). „NAD(P)H-dependent 6′-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract”. Arch. Biochem. Biophys. 261: 458-462. PMID 3355160.
- ↑ Heller, W. and Hahlbrock, K. (1980). „H'ighly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone”. Arch. Biochem. Biophys. 200: 617-619. PMID 7436427.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.