Eritroza-4-fosfat dehidrogenaza
| Eritroza-4-fosfat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.72 | ||||||||
| CAS broj | 131554-04-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Eritroza-4-fosfat dehidrogenaza (EC 1.2.1.72, eritroza 4-fosfatna dehidrogenaza, E4PDH, GapB, Epd dehidrogenaza, E4P dehidrogenaza) je enzim sa sistematskim imenom D-eritroza 4-fosfat:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- D-eritroza 4-fosfat + NAD+ +H2O 4-fosfoeritronat + NADH + 2 H+
Za ovaj enzim se originalno mislilo da je gliceraldehid-3-fosfatna dehidrogenaza (EC 1.2.1.12), ali je pokazano da to nije slučaj, jer gliceraldehid 3-fosfat nije supstrat. On formira deo puta biosinteze piridoksal-5'-fosfat koenzima kod Escherichia coli, zajedno sa EC 1.1.1.290 (4-fosfoeritronat dehidrogenazom), EC 2.6.1.52 (fosfoserin transaminazom), EC 1.1.1.262 (4-hidroksitreonin-4-fosfat dehidrogenazom), EC 2.6.99.2 (piridoksin 5'-fosfat sintazom) i EC 1.4.3.5 (piridoksamin-fosfat oksidazom).
Reference[uredi | uredi kod]
- ↑ Zhao, G., Pease, A.J., Bharani, N. and Winkler, M.E. (1995). „Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5′-phosphate biosynthesis”. J. Bacteriol. 177: 2804-2812. PMID 7751290.
- ↑ Boschi-Muller, S., Azza, S., Pollastro, D., Corbier, C. and Branlant, G. (1997). „Comparative enzymatic properties of GapB-encoded erythrose-4-phosphate dehydrogenase of Escherichia coli and phosphorylating glyceraldehyde-3-phosphate dehydrogenase”. J. Biol. Chem. 272: 15106-15112. PMID 9182530.
- ↑ Yang, Y., Zhao, G., Man, T.K. and Winkler, M.E. (1998). „Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12”. J. Bacteriol. 180: 4294-4299. PMID 9696782.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.