Hidroksimetilglutaril-KoA reduktaza
(Preusmjereno sa stranice EC 1.1.1.88)
| Hidroksimetilglutaril-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.88 | ||||||||
| CAS broj | 37250-24-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hidroksimetilglutaril-KoA reduktaza (EC 1.1.1.88, beta-hidroksi-beta-metilglutaril koenzim A reduktaza, beta-hidroksi-beta-metilglutaril KoA-reduktaza, 3-hidroksi-3-metilglutaril koenzim A reduktaza, hidroksimetilglutaril koenzim A reduktaza) je enzim sa sistematskim imenom (R)-mevalonat:NAD+ oksidoreduktaza (KoA-acilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-mevalonat + KoA + 2 NAD+ 3-hidroksi-3-metilglutaril-KoA + 2 NADH + 2 H+
Reference[uredi | uredi kod]
- ↑ Fimognari, G.M. and Rodwell, V.W. (1965). „Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA)”. Biochemistry 4: 2086-2090.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.