L-2-hidroksikarboksilat dehidrogenaza (NAD+)
(Preusmjereno sa stranice EC 1.1.1.337)
| L-2-hidroksikarboksilat dehidrogenaza (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.337 | ||||||||
| CAS broj | 81210-65-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-2-hidroksikarboksilat dehidrogenaza (NAD+) (EC 1.1.1.337, (R)-sulfolaktat:NAD+ oksidoreduktaza, L-sulfolaktatna dehidrogenaza, (R)-sulfolaktatna dehidrogenaza, L-2-hidroksikiselina dehidrogenaza (NAD+), ComC) je enzim sa sistematskim imenom (2S)-2-hidroksikarboksilat:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2S)-2-hidroksikarboksilat + NAD+ 2-oksokarboksilat + NADH + H+
Enzim iz arheje Methanocaldococcus jannaschii deluje na višestruke (S)-2-hidroksikarboksilate uključujući (2R)-3-sulfolaktat, (S)-malat, (S)-laktat, i (S)-2-hidroksiglutarat. (2R)-3-sulfolaktat ima istu stereo konfiguraciju kao (2S)-2-hidroksikarboksilati.
Reference[uredi | uredi kod]
- ↑ Graupner, M., Xu, H. and White, R.H. (2000). „Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea”. J. Bacteriol. 182: 3688-3692. PMID 10850983.
- ↑ Graupner, M. and White, R.H. (2001). „The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea”. Biochim. Biophys. Acta 1548: 169-173. PMID 11451450.
- ↑ Graham, D.E. and White, R.H. (2002). „Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics”. Nat. Prod. Rep. 19: 133-147. PMID 12013276.
- ↑ Rein, U., Gueta, R., Denger, K., Ruff, J., Hollemeyer, K. and Cook, A.M. (2005). „Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA”. Microbiology 151: 737-747. PMID 15758220.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.