Hinat/šikimat dehidrogenaza
(Preusmjereno sa stranice EC 1.1.1.282)
| Hinat/šikimat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.282 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hinat/šikimat dehidrogenaza (EC 1.1.1.282, YdiB) je enzim sa sistematskim imenom L-hinat:NAD(P)+ 3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) L-hinat + NAD(P)+ 3-dehidrohinat + NAD(P)H + H+
- (2) šikimat + NAD(P)+ 3-dehidrošikimat + NAD(P)H + H+
Ovo je drugi enzim šikimatne dehidrogenaze nađen kod Escherichia coli. On se razlikuje od EC 1.1.1.25, šikimatne dehidrogenaze, po tome što može da koristi hinat I šikimat kao supstrat, i bilo NAD+ ili NADP+ kao akceptor.
Reference[uredi | uredi kod]
- ↑ Michel, G., Roszak, A.W., Sauvé, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. (2003). „Structures of shikimate dehydrogenase AroE and its paralog YdiB. A common structural framework for different activities”. J. Biol. Chem. 278: 19463-19472. PMID 12637497.
- ↑ Benach, J., Lee, I., Edstrom, W., Kuzin, A.P., Chiang, Y., Acton, T.B., Montelione, G.T. and Hunt, J.F. (2003). „The 2.3-Å crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase”. J. Biol. Chem. 278: 19176-19182. PMID 12624088.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.