7b-hidroksisteroid dehidrogenaza (NADP+)
(Preusmjereno sa stranice EC 1.1.1.201)
| 7b-hidroksisteroid dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.201 | ||||||||
| CAS broj | 79393-83-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
7b-hidroksisteroid dehidrogenaza (NADP+) (EC 1.1.1.201, NADP+-zavisna 7beta-hidroksisteroid dehidrogenaza, 7beta-hidroksisteroid dehidrogenaza (NADP+)) je enzim sa sistematskim imenom 7beta-hidroksisteroid:NADP+ 7-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 7beta-hidroksisteroid + NADP+ 7-oksosteroid + NADPH + H+
Ovaj enzim katalizuje oksidaciju 7beta-hidroksi grupe žučne kiseline kao što je ursodezoksiholat.
Reference[uredi | uredi kod]
- ↑ Hirano, S. and Masuda, N. (1982). „Characterization of NADP-dependent 7β-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens”. Appl. Environ. Microbiol. 43: 1057-1063. PMID 6954878.
- ↑ Macdonald, I.A. and Roach, P.D. (1981). „Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum”. Biochim. Biophys. Acta 665: 262-269. PMID 6945134.
- ↑ Macdonald, I.A., Rochon, Y.P., Hutchison, D.M. and Holdeman, L.V. (1982). „Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7β-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7α-hydroxysteroid dehydrogenase-elaborating organisms”. Appl. Environ. Microbiol. 44: 1187-1195. PMID 6758698.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.