Ditrans,policis-poliprenil difosfat sintaza ((2E,6E)-farnezil difosfat specifična)
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| Ditrans,policis-poliprenil difosfat sintaza ((2E,6E)-farnezil difosfat specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.87 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ditrans,policis-poliprenil difosfat sintaza ((2E,6E)-farnezil difosfat specifična) (EC 2.5.1.87, RER2, Rer2p, Rer2p Z-preniltransferaza, Srt1p, Srt2p Z-preniltransferaza, ACPT, dehidrodolihil difosfatna sintaza 1) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat cistransferaza (dodaje 10--55 izopentenilnih jedinica).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat + n izopentenil difosfat n difosfat + ditrans,policis-poliprenil difosfat (n = 10--55)
Ovaj enzim učestvuje u biosintezi dolihola (dugolančanog poliprenola) sa zasićenim alfa-izoprenskim jedinicama.
Reference[uredi | uredi kod]
- ↑ Sato, M., Fujisaki, S., Sato, K., Nishimura, Y. and Nakano, A. (2001). „Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis”. Genes Cells 6: 495-506. PMID 11442630.
- ↑ Poznanski, J. and Szkopinska, A. (2007). „Precise bacterial polyprenol length control fails in Saccharomyces cerevisiae”. Biopolymers 86: 155-164. PMID 17345630.
- ↑ Sato, M., Sato, K., Nishikawa, S., Hirata, A., Kato, J. and Nakano, A. (1999). „The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis”. Mol. Cell Biol. 19: 471-483. PMID 9858571.
- ↑ Oh, S.K., Han, K.H., Ryu, S.B. and Kang, H. (2000). „Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis”. J. Biol. Chem. 275: 18482-18488. PMID 10764783.
- ↑ Cunillera, N., Arro, M., Fores, O., Manzano, D. and Ferrer, A. (2000). „Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis”. FEBS Lett. 477: 170-174. PMID 10908715.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.