Dermatan 4-sulfotransferaza
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| Dermatan 4-sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.35 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Dermatan 4-sulfotransferaza (EC 2.8.2.35, dermatan-specifična N-acetilgalaktozamin 4-O-sulfotransferaza, dermatan-4-sulfotransferaza-1, dermatan-4-sulfotransferaza 1, D4ST-1, dermatan N-acetilgalaktozamin 4-O-sulfotransferaza, CHST14 protein, CHST14) je enzim sa sistematskim imenom 3'-fosfo-5'-adenilil sulfat:(dermatan)-N-acetil-D-galaktozamin 4-sulfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfo-5'-adenilil sulfat + [dermatan]-N-acetil-D-galaktozamin adenozin 3',5'-bisfosfat + [dermatan]-4-O-sulfo-N-acetil-D-galaktozamin
Sulfacija se odvija u 4-pozicija N-acetil-D-galaktozaminskih ostataka dermatana.
Reference[uredi | uredi kod]
- ↑ Evers, M.R., Xia, G., Kang, H.G., Schachner, M. and Baenziger, J.U. (2001). „Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase”. J. Biol. Chem. 276: 36344-36353. PMID 11470797.
- ↑ Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H. and Sugahara, K. (2003). „Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis”. J. Biol. Chem. 278: 36115-36127. PMID 12847091.
- ↑ Pacheco, B., Maccarana, M. and Malmstrom, A. (2009). „Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate”. Glycobiology 19: 1197-1203. PMID 19661164.
- ↑ Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J. and Sugahara, K. (2006). „Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases”. J. Biol. Chem. 281: 18942-18952. PMID 16702220.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.