Denileukin diftitoks

Iz Wikipedije, slobodne enciklopedije
Idi na navigaciju Idi na pretragu
Denileukin diftitoks
Klinički podaci
AHFS/Drugs.com diftitox.html Monografija
Identifikatori
CAS broj 173146-27-5
ATC kod L01XX29
DrugBank DB00004
ChEMBL[1] CHEMBL1201550 YesY
Hemijski podaci
Formula C2560H4042N678O799S17 
Mol. masa 57647,3 g/mol
Farmakokinetički podaci
Poluvreme eliminacije 70-80 min
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Intravenozno

Denileukin diftitoks (Ontak) je antineoplastični agens, dizajnirani protein koji je kombinacija interleukina 2 i toksina difterije. Ovaj molekul se vezuje za interleukin-2 receptore[2] i unosi toksin difterije u ćelija koje izražavaju te receptore, što dovodi do njihove smrti. Denileukin diftitoks se proizvodi u E. coli ekspresioni sistem.[3][4][5][6]

Reference[uredi - уреди | uredi izvor]

  1. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  2. Turturro F (2007). "Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders". Expert Rev Anticancer Ther 7 (1): 11–7. PMID 17187516. doi:10.1586/14737140.7.1.11. 
  3. Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7. PMID 17187516
  4. Park M, Liu GT, Piltz-Seymour J, Wisda CL, Rook AH, Junkins-Hopkins JM, Nasta SD, Kim EJ: Vision loss following denileukin diftitox treatment: a case report of possible posterior ischemic optic neuropathy. Leuk Lymphoma. 2007 Apr;48(4):808-11. PMID 17454642
  5. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMC 3013709. PMID 21059682. doi:10.1093/nar/gkq1126. 
  6. David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901–6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]

Star of life.svg Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).