Delta12-masna-kiselina desaturaza
| Delta12-masna-kiselina desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.19.6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Delta12-masna-kiselina desaturaza (EC 1.14.19.6, Delta12 masno kiselinska desaturaza, Delta12(omega6)-desaturaza, oleoil-KoA Delta12 desaturaza, Delta12 desaturaza, Delta12-desaturaza) je enzim sa sistematskim imenom acil-KoA,vodonik donor:kiseonik Delta12-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- acil-KoA + redukovani akceptor + O2 Delta12-acil-KoA + akceptor + 2H2O
U kvascu Lipomyces starkeyi i američkoj bubašvabi, ovaj mikrozomalni enzim konvertuje oleoil-KoA u linoleoil-KoA. Kod moljaca Cadra cautella i Spodoptera, on konvertuje (Z)-tetradek-9-enoinsku kiselinu (9Z,12E)-tetradeka-9,12-dienoinsku kiselinu, koja se redukuje i acetiluje čime se formira acetatni estar feromona.
- ↑ Borgeson, C.E., de Renobales, M. and Blomquist, G.J. (1990). „Characterization of the Δ12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate”. Biochim. Biophys. Acta 1047: 135-140. PMID 2248971.
- ↑ Jurenka, R.A. (1997). „Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a Δ12 desaturase”. Cell. Mol. Life Sci. 53: 501-505. PMID 9230926.
- ↑ Lomascolo, A., Dubreucq, E. and Galzy, P. (1996). „Study of the Δ12-desaturase system of Lipomyces starkeyi”. Lipids 31: 253-259. PMID 8900454.
- ↑ Tocher, D.R., Leaver, M.J. and Hodgson, P.A. (1998). „Recent advances in the biochemistry and molecular biology of fatty acyl desaturases”. Prog. Lipid Res. 37: 73-117. PMID 9829122.
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