DTDP-glukozna 4,6-dehidrataza
(Preusmjereno sa stranice DTDP-alpha-D-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-alpha-D-glucose-forming))
| DTDP-glukozna 4,6-dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.46 | ||||||||
| CAS broj | 37259-54-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DTDP-glukozna 4,6-dehidrataza (EC 4.2.1.46, timidin difosfoglukozna oksidoreduktaza, TDP-glukozna oksidoreduktaza, dTDP-glukozna 4,6-hidrolijaza, dTDP-glukoza 4,6-hidrolijaza (formira dTDP-4-dehidro-6-dezoksi-alfa-D-glukoza)) je enzim sa sistematskim imenom dTDP-alfa-D-glukoza 4,6-hidrolijaza (formira dTDP-4-dehidro-6-dezoksi-alfa-D-glukoza).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dTDP-alfa-D-glukoza dTDP-4-dehidro-6-dezoksi-alfa-D-glukoza + H2O
Za dejstvo ovog enzima je neophodan NAD+.
- ↑ Gilbert, J.M., Matsuhashi, M. and Strominger, J.L. (1965). „Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. II. Purification and properties of thymidine diphosphate D-glucose oxidoreductase”. J. Biol. Chem. 240: 1305-1308. PMID 14284740.
- ↑ Melo, A., Elliott, H. and Glaser, L. (1968). „The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase”. J. Biol. Chem. 243: 1467-1474. PMID 4869560.
- ↑ Wang, S.-F. and Gabriel, O. (1969). „Biological mechanisms involved in the formation of deoxy sugars. V. Isolation and crystallization of thymidine diphosphate-D-glucose oxidoreductase from Escherichia coli B”. J. Biol. Chem. 244: 3430-3437. PMID 4307450.
- ↑ Hegeman, A.D., Gross, J.W. and Frey, P.A. (2001). „Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site”. Biochemistry 40: 6598-6610. PMID 11380254.
- ↑ Gross, J.W., Hegeman, A.D., Gerratana, B. and Frey, P.A. (2001). „Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase”. Biochemistry 40: 12497-12504. PMID 11601973.
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