DNK oksidativna demetilaza
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| DNK oksidativna demetilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.33 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
DNK oksidativna demetilaza (EC 1.14.11.33, protein popravke alkilisane DNK, alfa-ketoglutarat-zavisna dioksigenaza ABH1, alkB (gen)) je enzim sa sistematskim imenom metil DNA-base, 2-oksoglutarat:kiseonik oksidoreduktaza (formira formaldehid).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- DNK-baza-CH3 + 2-oksoglutarat + O2 DNK-baza + formaldehid + sukcinat + CO2
Ovaj enzim sadrži gvožđe. Njegovo dejstvo u maloj meri stimuliše askorbat.
Reference[uredi | uredi kod]
- ↑ Falnes, P.O., Johansen, R.F. and Seeberg, E. (2002). „AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli”. Nature 419: 178-182. PMID 12226668.
- ↑ Yi, C., Yang, C.G. and He, C. (2009). „A non-heme iron-mediated chemical demethylation in DNA and RNA”. Acc. Chem. Res. 42: 519-529. PMID 19852088.
- ↑ Yi, C., Jia, G., Hou, G., Dai, Q., Zhang, W., Zheng, G., Jian, X., Yang, C.G., Cui, Q. and He, C. (2010). „Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase”. Nature 468: 330-333. PMID 21068844.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.