Peptidilprolilna izomeraza

Iz Wikipedije, slobodne enciklopedije
(Preusmjereno sa Ciklofilin)
Idi na navigaciju Idi na pretragu
Peptidilprolilna izomeraza
PDB 1nmw EBI.jpg
Identifikatori
EC broj 5.2.1.8
CAS broj 95076-93-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Peptidilprolilna izomeraza (EC 5.2.1.8, PPIaza, ciklofilin, peptid vezana izomeraza, peptidilna-prolil cis-trans izomeraza) je enzim sa sistematskim imenom peptidilprolin cis-trans-izomeraza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidilnaprolin (omega = 180) peptidilnaprolin (omega = 0)

Prvi pronađeni tip ovog enzima je proteinski ciklofilin, koji vezuje imunosupresant ciklosporin A. Postoje druge distinktne familije. Među njima su FK-506 vezujući proteini (FKBP).

Reference[uredi - уреди | uredi izvor]

  1. Fischer, G. and Bang, H. (1985). "The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase". Biochim. Biophys. Acta 828: 39–42. PMID 3882150. 
  2. Fischer, G., Bang, H. and Mech, C. (1984). "[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides]". Biomed. Biochim. Acta 43: 1101–1111. PMID 6395866. 
  3. Fischer, G., Wittmann-Liebold, B., Lang, K., Kiefhaber, T. and Schmid, F.X. (1989). "Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins". Nature 337: 476–478. PMID 2492638. 
  4. Takahashi, N., Hayano, T. and Suzuki, M. (1989). "Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin". Nature 337: 473–475. PMID 2644542. 
  5. Hennig, L., Christner, C., Kipping, M., Schelbert, B., Rucknagel, K.P., Grabley, S., Kullertz, G. and Fischer, G. (1998). "Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone". Biochemistry 37: 5953–5960. PMID 9558330. 
  6. Fischer, G. (1994). "Peptidyl-prolyl cis/trans isomerases and their effectors". Angew. Chem. Int. Ed. Engl. 33: 1415–1436. 
  7. Harrison, R.K. and Stein, R.L. (1990). "Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes". Biochemistry 29: 3813–3816. PMID 1693856. 
  8. Eisenmesser, E.Z., Bosco, D.A., Akke, M. and Kern, D. (2002). "Enzyme dynamics during catalysis". Science 295: 1520–1523. PMID 11859194. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]