Hondroitin-sulfat-ABC endolijaza
(Preusmjereno sa stranice ChS ABC lyase)
| Hondroitin-sulfat-ABC endolijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.20 | ||||||||
| CAS broj | 9024-13-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hondroitin-sulfat-ABC endolijaza (EC 4.2.2.20, hondroitinaza, hondroitin ABC eliminaza, hondroitinaza ABC, hondroitin ABC lijaza, hondroitin sulfat ABC lijaza, ChS ABC lijaza, hondroitin sulfat ABC endoeliminaza, hondroitin sulfat ABC endolijaza, ChS ABC lijaza I) je enzim sa sistematskim imenom hondroitin-sulfat-ABC endolijaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endolitičko razlaganje (1->4)-beta-galaktozaminskih veza između N-acetilgalaktozamina i bilo D-glukuronske kiseline ili L-iduronske kiseline čime se formira smeša Delta4-nezasićenih oligosaharida različitih veličina koji se ultimatno degradiraju do Delta4-nezasićenih tetra- i disaharida
Ovaj enzim degradira mnoštvo glikozaminoglikana hondroitin-sulfat- i dermatan-sulfatnog tipa.
Reference[uredi | uredi kod]
- ↑ Yamagata, T., Saito, H., Habuchi, O. and Suzuki, S. (1968). „Purification and properties of bacterial chondroitinases and chondrosulfatases”. J. Biol. Chem. 243: 1523-1535. PMID 5647268.
- ↑ Saito, H., Yamagata, T. and Suzuki, S. (1968). „Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates”. J. Biol. Chem. 243: 1536-1542. PMID 4231029.
- ↑ Suzuki, S., Saito, H., Yamagata, T., Anno, K., Seno, N., Kawai, Y. and Furuhashi, T. (1968). „Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion”. J. Biol. Chem. 243: 1543-1550. PMID 5647269.
- ↑ Hamai, A., Hashimoto, N., Mochizuki, H., Kato, F., Makiguchi, Y., Horie, K. and Suzuki, S. (1997). „Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides”. J. Biol. Chem. 272: 9123-9130. PMID 9083041.
- ↑ Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276-6286. PMID 16336265.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.