A-N-acetilneuraminat a-2,8-sijaliltransferaza
(Preusmjereno sa stranice CMP-NeuAc:LM1(alfa2-8) sijaliltranferaza)
| A-N-acetilneuraminat a-2,8-sijaliltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.8 | ||||||||
| CAS broj | 67339-00-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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A-N-acetilneuraminat a-2,8-sijaliltransferaza (EC 2.4.99.8, citidin monofosfoacetilneuraminat-gangliozid GM3, alfa-2,8-sijaliltransferaza, gangliozid GD3 sintaza, gangliozid GD3 sintetaza sijaliltransferaza, CMP-NeuAc:LM1(alfa2-8) sijaliltranferaza, GD3 sintaza, SAT-2) je enzim sa sistematskim imenom CMP-N-acetilneuraminat:alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozid alfa-(2->8)-N-acetilneuraminiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CMP-N-acetilneuraminat + alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-R CMP + alfa-N-acetilneuraminil-(2->8)-alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-R
Gangliozidi mogu da deluju kao akceptori.
Reference[uredi | uredi kod]
- ↑ Eppler, M.C., Morré, J.D. and Keenan, T.W. (1980). „Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides”. Biochim. Biophys. Acta 619: 332-343. PMID 7407217.
- ↑ Higashi, H., Basu, M. and Basu, S. (1985). „Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain”. J. Biol. Chem. 260: 824-828. PMID 3838172.
- ↑ McCoy, R.D., Vimr, E.R. and Troy, F.A. (1985). „CMP-NeuNAc:poly-α-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules”. J. Biol. Chem. 260: 12695-12699. PMID 4044605.
- ↑ Yohe, H.C. and Yu, R.K. In vitro biosynthesis of an isomer of brain trisialoganglioside, GT (1980). „1a”. J. Biol. Chem. 255: 608-613. PMID 6766128.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.