N2-(2-karboksietil)arginin sintaza
(Preusmjereno sa stranice CEA synthetase)
| N2-(2-karboksietil)arginin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.66 | ||||||||
| CAS broj | 250207-48-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N2-(2-karboksietil)arginin sintaza (EC 2.5.1.66, CEAS, N2-(2-karboksietil)arginin sintetaza, CEA sintetaza, gliceraldehid-3-fosfat:L-arginin 2-N-(2-hidroksi-3-oksopropil) transferaza (formira 2-karboksietil)) je enzim sa sistematskim imenom gliceraldehid-3-fosfat:L-arginin N2-(2-hidroksi-3-oksopropil) transferaza (formira 2-karboksietil).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za dejstvo ovog enzima je neophodan tiamin difosfat. On katalizuje prvi korak u biosintezi klavulanske kiseline.
Reference[uredi | uredi kod]
- ↑ Caines, M.E.C., Elkins, J.M., Hewitson, K.S. and Schofield, C.J. (2004). „Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzymes in the clavulanic acid biosynthesis pathway”. J. Biol. Chem. 279: 5685-5692. PMID 14623876.
- ↑ Khaleeli, N., Li, R. and Townsend, C.A. (1999). „Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction”. J. Am. Chem. Soc. 121: 9223-9224.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.