BD-1008
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 2-(3,4-dichlorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylethyl)ethanamine | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 138356-08-8 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 126388 | ||
| Hemijski podaci | |||
| Formula | C15H22Cl2N2 | ||
| Mol. masa | 301.254 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
BD-1008 je antagonist sigma receptora, koji blokira efekte kokaina u studijama na životinjama. On potencijalno može da bude koristan u razvoju antidota za lečenje kokainskog predoziranja.[3][4][5][6]
Vidi još[uredi | uredi kod]
Literatura[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Monnet FP, de Costa BR, Bowen WD (September 1996). „Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H-noradrenaline release in rat hippocampal slices”]. British Journal of Pharmacology 119 (1): 65–72. PMC 1915737. PMID 8872358.
- ↑ Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (January 2001). „N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice”. European Journal of Pharmacology 411 (3): 261–73. PMID 11164383.
- ↑ Matsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD (May 2001). „Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice”. European Journal of Pharmacology 419 (2-3): 163–74. DOI:10.1016/S0014-2999(01)00968-2. PMID 11426838.
- ↑ Matsumoto RR, Gilmore DL, Pouw B, Bowen WD, Williams W, Kausar A, Coop A (May 2004). „Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice”. European Journal of Pharmacology 492 (1): 21–6. DOI:10.1016/j.ejphar.2004.03.037. PMID 15145701.
