Alfa 1-antitripsin

Inhibitor serpinske peptidaze, grupa A (alfa-1 antiproteinaza, antitripsin), član 1
	; Kristalna struktura serpina A1 (red) u inhibitornom kompleksu sa pankreatičkom elastazom (plavo). Prikaz je baziran na 2D26.
Dostupne strukture
	1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD, 3NDF, 3NE4, 3T1P, 7API, 8API, 9API
Identifikatori
Simboli	SERPINA1; A1A; A1AT; AAT; PI; PI1; PRO2275; alpha1AT
Vanjski ID	OMIM: 107400 MGI: 891971 HomoloGene: 20103 GeneCards: SERPINA1 Gene
Ontologija gena
Molekularna funkcija	• vezivanje proteaze; • aktivnost inhibitora serinskog tipa endopeptidaze; • proteinsko vezivanje;
Celularna komponenta	• ekstracelularni region; • proteinski ekstracelularni matriks; • ekstracelularni prostor;
Biološki proces	• respons na hipoksiju; • degranulacija trombocita; • respons akutne faze;
Pregled RNK izražavanja
	podaci
Ortolozi

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Alfa 1-antitripsin ili α₁-antitripsin (A1AT) je proteazni inhibitor iz serpinske superfamilije. On je generalno poznat kao serumski tripsinski inhibitor. Alfa 1-antitripsin se takođe naziva alfa-1 proteinazni inhibitor (A1PI), jer inhibira širok opseg proteaza.^[1] On štiti tkiva od enzima inflamatornih ćelija, posebno neutrofilne elastaze, i ima referentni opseg u krvi od 1,5 - 3,5 gram/litre, mada koncentracija može da bude znatno viša nakon akutne inflamacije.^[2] U njegovom odsustvu, neutrofilna elastaza nesmetano razlaže elastin, koji doprinosi elastičnosti pluća, što stvara respiratorne probleme, kao što je emfisema.

Reference

↑ Gettins PG (2002). „Serpin structure, mechanism, and function”. Chem Rev 102 (12): 4751–804. DOI:10.1021/cr010170. PMID 12475206.
↑ Kushner, Mackiewicz A (1993). The acute phase response: an overview.. CRC Press. str. 3–19.

Literatura

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