Glicin C-acetiltransferaza
(Preusmjereno sa stranice AKB ligase)
| Glicin C-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.29 | ||||||||
| CAS broj | 37257-11-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glicin C-acetiltransferaza (EC 2.3.1.29, 2-amino-3-ketobutirat KoA ligaza, 2-amino-3-ketobutirat koenzim A ligaza, 2-amino-3-ketobutirat-KoA ligaza, glicin acetiltransferaza, aminoaceton sintaza, aminoaceton sintetaza, KBL, AKB ligaza) je enzim sa sistematskim imenom acetil-KoA:glicin C-acetiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + glicin KoA + L-2-amino-3-oksobutanoat
Ovaj piridoksal-fosfat-zavisni enzim deluje zajedno sa EC 1.1.1.103, L-treonin 3-dehidrogenazom, tokom degradacije treonina čime se formira glicin.
Reference[uredi | uredi kod]
- ↑ McGilvray, D. and Morris, J.G. (1969). „U'tilization of L-threonine by a species of Arthrobacter. A novel catabolic role for "aminoacetone synthase"”. Biochem. J. 112: 657-671. PMID 5821726.
- ↑ Mukherjee, J.J. and Dekker, E.E. (1987). „Purification, properties, and N-terminal amino acid sequence of homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a pyridoxal phosphate-dependent enzyme”. J. Biol. Chem. 262: 14441-14447. PMID 3117785.
- ↑ Edgar, A.J. and Polak, J.M. (2000). „Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs”. Eur. J. Biochem. 267: 1805-1812. PMID 10712613.
- ↑ Schmidt, A., Sivaraman, J., Li, Y., Larocque, R., Barbosa, J.A., Smith, C., Matte, A., Schrag, J.D. and Cygler, M. (2001). „Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism”. Biochemistry 40: 5151-5160. PMID 11318637.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.