ADP-ribozilargininska hidrolaza

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ADP-ribozilargininska hidrolaza
Identifikatori
EC broj 3.2.2.19
CAS broj 98668-52-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

ADP-ribozilargininska hidrolaza (EC 3.2.2.19, enzim razlaganja ADP-riboza-L-arginina, Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza, protein-omega-N-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza) je enzim sa sistematskim imenom protein-Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) protein-Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + protein-L-arginin
(2) Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + L-arginin

Ovaj enzim uklanja ADP-ribozu sa argininskih ostataka u ADP-ribozilisanim proteinima.

Reference[uredi - уреди | uredi izvor]

  1. Moss, J., Jacobson, M.K. and Stanley, S.J. (1985). "Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme". Proc. Natl. Acad. Sci. USA 82: 5603–5607. PMID 2994036. 
  2. Moss, J., Stanley, S.J., Nightingale, M.S., Murtagh, J.J., Jr., Monaco, L., Mishima, K., Chen, H.C., Williamson, K.C. and Tsai, S.C. (1992). "Molecular and immunological characterization of ADP-ribosylarginine hydrolases". J. Biol. Chem. 267: 10481–10488. PMID 1375222. 
  3. Konczalik, P. and Moss, J. (1999). "Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases". J. Biol. Chem. 274: 16736–16740. PMID 10358013. 
  4. Takada, T., Iida, K. and Moss, J. (1993). "Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase". J. Biol. Chem. 268: 17837–17843. PMID 8349667. 
  5. Ohno, T., Tsuchiya, M., Osago, H., Hara, N., Jidoi, J. and Shimoyama, M. (1995). "Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase". Anal. Biochem. 10: 115–122. PMID 8678289. 

Literatura[uredi - уреди | uredi izvor]

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