ADAM 17 endopeptidaza
(Preusmjereno sa stranice ADAM-17 endopeptidaza)
| ADAM 17 endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.86 | ||||||||
| CAS broj | 151769-16-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
ADAM 17 endopeptidaza (EC 3.4.24.86, tumorno nekrozni faktor alfa-konvertujući enzim, TACE) je enzim.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Uska endopeptidazna specifičnost. Razlaže Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser u za membranu vezanoj, 26 kDa formi tumornog nekroznog faktora alfa (TNFalfa). Slično tome razlaže druge za površinu ćelijske membrane vezane proteine, čime se odvajaju ekstracelularni domeni
Ovaj enzim pripada peptidaznoj familiji M12.
Reference[uredi | uredi kod]
- ↑ Black, R.A. (2002). „Tumor necrosis factor-α converting enzyme. Int. J”. Biochem. Cell Biol. 34: 1-5. PMID 11733179.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.