Acil-KoA dehidrogenaza dugog lanca
(Preusmjereno sa stranice ACADL (gene name).)
| Acil-KoA dehidrogenaza dugog lanca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.8.8 | ||||||||
| CAS broj | 59536-74-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acil-KoA dehidrogenaza dugog lanca (EC 1.3.8.8, palmitoil-KoA dehidrogenaza, palmitoil-koenzim A dehidrogenaza, acil-koenzim A dehidrogenaza dugog lanca, acil-KoA dugog lanca:(akceptor) 2,3-oksidoreduktaza, ACADL (gen).) je enzim sa sistematskim imenom acil-KoA dugog lanca:elektron-transfer flavoprotein 2,3-oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dugolančani acil-KoA + elektron-transfer flavoprotein dugolančani trans-2,3-dehidroacil-KoA + redukovani elektron-transfer flavoprotein
Ovaj enzim dadrži FAD kao prostetičku grupu. On je jedan od nekoliko enzima koji katalizuju prvi kora u beta oksidaciji masnih kiselina.
Reference[uredi | uredi kod]
- ↑ Crane, F.L., Hauge, J.G. and Beinert, H. (1955). „Flavoproteins involved in the first oxidative step of the fatty acid cycle”. Biochim. Biophys. Acta 17: 292-294. PMID 13239683.
- ↑ Hauge, J.G., Crane, F.L. and Beinert, H. (1956). „On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl CoA dehydrogenase”. J. Biol. Chem. 219: 727-733. PMID 13319294.
- ↑ Hall, C.L., Heijkenkjold, L., Bartfai, T., Ernster, L. and Kamin, H. (1976). „Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef heart mitochondria”. Arch. Biochem. Biophys. 177: 402-414. PMID 1015826.
- ↑ Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). „Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme”. J. Biol. Chem. 260: 1311-1325. PMID 3968063.
- ↑ Djordjevic, S., Dong, Y., Paschke, R., Frerman, F.E., Strauss, A.W. and Kim, J.J. (1994). „Identification of the catalytic base in long chain acyl-CoA dehydrogenase”. Biochemistry 33: 4258-4264. PMID 8155643.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.