9beta-pimara-7,15-dien oksidaza
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| 9beta-pimara-7,15-dien oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.144 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
9beta-pimara-7,15-dien oksidaza (EC 1.14.13.144, CYP99A3) je enzim sa sistematskim imenom 9beta-pimara-7,15-dien,NADPH:kiseonik 19-oksidoreduktaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 9beta-pimara-7,15-dien + 3 O2 + 3 NADPH + 3 H+ 9beta-pimara-7,15-dien-19-oat + 3 NADP+ + 4H2O (sveukupna reakcija)
- (1a) 9beta-pimara-7,15-dien + O2 + NADPH + H+ 9beta-pimara-7,15-dien-19-ol + NADP+ + H2O
- (1b) 9beta-pimara-7,15-dien-19-ol + O2 + NADPH + H+ 9beta-pimara-7,15-dien-19-al + NADP+ + 2H2O
- (1c) 9beta-pimara-7,15-dien-19-al + O2 + NADPH + H+ 9beta-pimara-7,15-dien-19-oat + NADP+ + H2O
Za rad ovog enzima je neophodan citohrom P450. Enzim iz pirinča, Oryza sativa, učestvujeu u biosintezi fitoaleksinskog momilaktona.
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.