9,12-Oktadekadienoat 8-hidroperoksidna 8S-izomeraza
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| 9,12-Oktadekadienoat 8-hidroperoksidna 8S-izomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.4.6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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9,12-Oktadekadienoat 8-hidroperoksidna 8S-izomeraza (EC 5.4.4.6, 8-hidroperoksidna izomeraza, (8R,9Z,12Z)-8-hidroperoksi-9,12-oktadekadienoatna mutaza (formira (7S,8S,9Z,12Z)-7,8-dihidroksi-9,12-oktadekadienoat)) je enzim sa sistematskim imenom (8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat hidroksimutaza (formira (7S,8S,9Z,12Z)-7,8-dihidroksioktadeka-9,12-dienoat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat (7S,8S,9Z,12Z)-7,8-dihidroksioktadeka-9,12-dienoat
Ovaj enzim sadrži hem.
Reference[uredi | uredi kod]
- ↑ Hamberg, M., Zhang, L.-Y., Brodowsky, I.D. and Oliw, E.H. (1994). „Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions”. Arch. Biochem. Biophys. 309: 77-80. PMID 8117115.
- ↑ Su, C., Sahlin, M. and Oliw, E.H. (1998). „A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities”. J. Biol. Chem. 273: 20744-20751. PMID 9694817.
- ↑ Su, C. and Oliw, E.H. (1996). „Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein”. J. Biol. Chem. 271: 14112-14118. PMID 8662736.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.