7-hloro-L-triptofan oksidaza
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| 7-hloro-L-triptofan oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.3.23 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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7-hloro-L-triptofan oksidaza (EC 1.4.3.23, RebO) je enzim sa sistematskim imenom 7-hloro-L-triptofan:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 7-hloro-L-triptofan + O2 2-imino-3-(7-hloroindol-3-il)propanoat +H2O2
Ovaj enzim sadrži nekovalentno vezani FAD. Ovaj enzim katalizuje prvi korak biosinteze rebekamicina, indolokarbazolnog alkaloida koji formira Actinobakterija Lechevalieria.
Reference[uredi | uredi kod]
- ↑ Nishizawa, T., Aldrich, C.C. and Sherman, D.H. (2005). „Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243”. J. Bacteriol. 187: 2084-2092. PMID 15743957.
- ↑ Howard-Jones, A.R. and Walsh, C.T. (2005). „Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD”. Biochemistry 44: 15652-15663. PMID 16313168.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.