6-Hidroksinikotinat dehidrogenaza
(Preusmjereno sa stranice 6-hydroxynicotinate hydroxylase)
| 6-hidroksinikotinat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.3.3 | ||||||||
| CAS broj | 122191-32-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
6-hidroksinikotinat dehidrogenaza (EC 1.17.3.3, 6-hidroksinikotinsko kiselinska hidroksilaza, 6-hidroksinikotinsko kiselinska dehidrogenaza, 6-hidroksinikotinatna hidroksilaza) je enzim sa sistematskim imenom 6-hidroksinikotinat:O2 oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 6-hidroksinikotinat + H2O + O2 2,6-dihidroksinikotinat + H2O2
Ovaj enzim sadrži [2Fe-2S] gvožđe-sumporne centre, FAD i molibden.
Reference[uredi | uredi kod]
- ↑ Nagel, M. and Andreesen, J.R. (1989). „Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923”. FEMS Microbiol. Lett. 59: 147-152.
- ↑ Nagel, M. and Andreesen, J.R. (1990). „Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini”. Arch. Microbiol. 154: 605-613.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.