Pirolohinolin-hinon sintaza
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| Pirolohinolin-hinon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.3.11 | ||||||||
| CAS broj | 353484-42-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Pirolohinolin-hinon sintaza (EC 1.3.3.11, PqqC, 6-(2-amino-2-karboksietil)-7,8-diokso-1,2,3,4,5,6,7,8-oktahidrohinolin-2,4-dikarboksilat:kiseonik oksidoreduktaza (ciklizacija)) je enzim sa sistematskim imenom 6-(2-amino-2-karboksietil)-7,8-diokso-1,2,3,4,7,8-heksahidrohinolin-2,4-dikarboksilat:kiseonik oksidoreduktaza (ciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 6-(2-amino-2-karboksietil)-7,8-diokso-1,2,3,4,7,8-heksahidrohinolin-2,4-dikarboksilat + 3 O2 4,5-diokso-4,5-dihidro-1H-pirolo[2,3-f]hinolin-2,7,9-trikarboksilat + 2H2O2 + 2H2O
Za rad ovog enzima je neophodna jedna za sad neophodna komponenta da bi došlo do oslobađanja njegovog produkta.
Reference[uredi | uredi kod]
- ↑ Magnusson, O.T., Toyama, H., Saeki, M., Schwarzenbacher, R. and Klinman, J.P. (2004). „The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis”. J. Am. Chem. Soc. 126: 5342-5343. PMID 15113189.
- ↑ Magnusson, O.T., Toyama, H., Saeki, M., Rojas, A., Reed, J.C., Liddington, R.C., Klinman, J.P. and Schwarzenbacher, R. (2004). „Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone”. Proc. Natl. Acad. Sci. USA 101: 7913-7918. PMID 15148379.
- ↑ Toyama, H., Chistoserdova, L. and Lidstrom, M.E. (1997). „Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate”. Microbiology 143: 595-602. PMID 9043136.
- ↑ Toyama, H., Fukumoto, H., Saeki, M., Matsushita, K., Adachi, O. and Lidstrom, M.E. (2002). „PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone”. Biochem. Biophys. Res. Commun. 299: 268-272. PMID 1243798.
- ↑ Schwarzenbacher, R., Stenner-Liewen, F., Liewen, H., Reed, J.C. and Liddington, R.C. (2004). „Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution”. Proteins 56: 401-403. PMID 15211525.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.