6,7-dihidropteridin reduktaza
(Preusmjereno sa stranice 6,7-dihydropteridine reductase)
| 6,7-dihidropteridin reduktaza | |||||||||
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| Dihidropteridin reduktaza dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.5.1.34 | ||||||||
| CAS broj | 2620562 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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6,7-dihidropteridin reduktaza (EC 1.5.1.34, 6,7-dihidropteridin:NAD(P)H oksidoreduktaza, DHPR, NAD(P)H:6,7-dihidropteridin oksidoreduktaza, NADH-dihidropteridin reduktaza, NADPH-dihidropteridin reduktaza, NADPH-specifična dihidropteridinska reduktaza, dihidropteridin (redukovani nikotinamid adenin dinukleotid) reduktaza, dihidropteridinska reduktaza, dihidropteridinska reduktaza (NADH), 5,6,7,8-tetrahidropteridin:NAD(P)H+ oksidoreduktaza) je enzim sa sistematskim imenom 5,6,7,8-tetrahidropteridin:NAD(P)+ oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5,6,7,8-tetrahidropteridin + NAD(P)+ 6,7-dihidropteridin + NAD(P)H + H+
Supstrat je hinonoidna forma dihidropteridina. Ovaj enzim se razlikuje od EC 1.5.1.3, dihidrofolatne reduktaze.
Reference[uredi | uredi kod]
- ↑ Harano, T. (1972). „New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin”. Insect Biochem. 2: 385-399.
- ↑ Hasegawa, H. (1977). „Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH”. J. Biochem. (Tokyo) 81: 169-177. PMID 191436.
- ↑ Kaufman, S. (1962). „Phenylalanine hydroxylase”. Methods Enzymol. 5: 809-816.
- ↑ Lind, K.E. (1972). „Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines”. Eur. J. Biochem. 25: 560-562. PMID 4402916.
- ↑ Nakanishi, N., Hasegawa, H. and Watabe, S. (1977). „A new enzyme, NADPH-dihydropteridine reductase in bovine liver”. J. Biochem. (Tokyo) 81: 681-685. PMID 16875.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.