5-Fosfonooksi-L-lizinska fosfo-lijaza
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| 5-Fosfonooksi-L-lizinska fosfo-lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.134 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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5-Fosfonooksi-L-lizinska fosfo-lijaza (EC 4.2.3.134, 5-fosfohidroksi-L-lizin amoniofosfolijaza, AGXT2L2 (gen)) je enzim sa sistematskim imenom (5R)-5-fosfonooksi-L-lizin fosfat-lijaza (deaminacija, formira (S)-2-amino-6-oksoheksanoat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5R)-5-fosfonooksi-L-lizin +H2O (S)-2-amino-6-oksoheksanoat + NH3 + fosfat
Ovaj enzim je piridoksal-fosfatni protein.
Reference[uredi | uredi kod]
- ↑ Tsai, C.H. and Henderson, L.M. (1974). „Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase”. J. Biol. Chem. 249: 5784-5789. PMID 4412716.
- ↑ Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V. and Van Schaftingen, E. (2012). „Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine”. J. Biol. Chem. 287: 7246-7255. PMID 22241472.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.