5,6-Dimetilbenzimidazol sintaza
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| 5,6-Dimetilbenzimidazol sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.40 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
5,6-Dimetilbenzimidazol sintaza (EC 1.14.99.40, BLUB) je enzim sa sistematskim imenom FMNH2 oksidoreduktaza (formira 5,6-dimetilbenzimidazol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- FMNH2 + NADH + H+ + O2 5,6-dimetilbenzimidazol + D-eritroza 4-fosfat + NAD+ + drugi produkt
C-2 atom iza 5,6-dimetilbenzimidazola je izveden iz C-1' ribitilne grupe FMNH2, dok je 2-H iz ribitil 1'-pro-S vodonika. Drugi produkt može da bude barbiturna kiselina.
Reference[uredi | uredi kod]
- ↑ Gray, M.J. and Escalante-Semerena, J.C. (2007). „Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12”. Proc. Natl. Acad. Sci. USA 104: 2921-2926. PMID 17301238.
- ↑ Ealick, S.E. and Begley, T.P. (2007). „Biochemistry: molecular cannibalism”. Nature 446: 387-388. PMID 17377573.
- ↑ Taga, M.E., Larsen, N.A., Howard-Jones, A.R., Walsh, C.T. and Walker, G.C. (2007). „BluB cannibalizes flavin to form the lower ligand of vitamin B12”. Nature 446: #449-453. PMID 17377583.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.