4,4'-diapofitoen desaturaza
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| 4,4'-diapofitoen desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.8.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4,4'-diapofitoen desaturaza (EC 1.3.8.2, dehidroskvalenska desaturaza, CrtN, 4,4'-diapofitoen:FAD oksidoreduktaza) je enzim sa sistematskim imenom 15-cis-4,4'-diapofitoen:FAD oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 15-cis-4,4'-diapofitoen + 4 FAD sve--trans-4,4'-diapolikopen + 4 FADH2 (sveukupna reakcija)
- (1a) 15-cis-4,4'-diapofitoen + FAD sve-trans-4,4'-diapofitofluen + FADH2
- (1b) sve-trans-4,4'-diapofitofluen + FAD sve-trans-4,4'-diapo-zeta-karoten + FADH2
- (1c) sve-trans-4,4'-diapo-zeta-karoten + FAD sve-trans-4,4'-diaponeurosporen + FADH2
- (1d) sve-trans-4,4'-diaponeurosporen + FAD sve-trans-4,4'-diapolikopen + FADH2
Ovaj enzim je tipičan za Staphylococcus aureus i neke druge bakterije kao što je Heliobacillus sp. On je odgovoran za četiri sukcesivne dehidrogenacije.
Reference[uredi | uredi kod]
- ↑ Wieland, B., Feil, C., Gloria-Maercker, E., Thumm, G., Lechner, M., Bravo, J.M., Poralla, K. and Gotz, F. (1994). „Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4′-diaponeurosporene of Staphylococcus aureus”. J. Bacteriol. 176: 7719-7726. PMID 8002598.
- ↑ Raisig, A. and Sandmann, G. (1999). „4,4′-diapophytoene desaturase: catalytic properties of an enzyme from the C30 carotenoid pathway of Staphylococcus aureus”. J. Bacteriol. 181: 6184-6187. PMID 10498735.
- ↑ Raisig, A. and Sandmann, G. (2001). „Functional properties of diapophytoene and related desaturases of C30 to C40 carotenoid biosynthetic pathways”. Biochim. Biophys. Acta 1533: 164-170. PMID 11566453.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.