23S rRNK (uridin2552-2'-O)-metiltransferaza
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| 23S rRNK (uridin2552-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.166 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK (uridin2552-2'-O)-metiltransferaza (EC 2.1.1.166, Um(2552) 23S ribosomal RNK metiltransferaza, protein toplotnog šoka RrmJ, RrmJ, FTSJ, Um2552 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (uridin2552-2'-O-)-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + uridin2552 in 23S rRNK S-adenozil-L-homocistein + 2'-O-metiluridin2552 in 23S rRNK
Ovaj enzim katalizuje 2'-O-metilaciju univerzalno konzerviranog U2552 u A petlji 23S rRNK.
Reference[uredi | uredi kod]
- ↑ Caldas, T., Binet, E., Bouloc, P., Costa, A., Desgres, J. and Richarme, G. (2000). „The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase”. J. Biol. Chem. 275: 16414-16419. PMID 10748051.
- ↑ Hager, J., Staker, B.L., Bugl, H. and Jakob, U. (2002). „Active site in RrmJ, a heat shock-induced methyltransferase”. J. Biol. Chem. 277: 41978-41986. PMID 12181314.
- ↑ Hager, J., Staker, B.L. and Jakob, U. (2004). „Substrate binding analysis of the 23S rRNA methyltransferase RrmJ”. J. Bacteriol. 186: 6634-6642. PMID 15375145.
- ↑ Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C. and Jakob, U. (2000). „RNA methylation under heat shock control”. Mol. Cell 6: 349-360. PMID 10983982.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.