23S rRNK (guanin2069-N7)-metiltransferaza
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23S rRNK (guanin2069-N7)-metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.264 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK (guanin2069-N7)-metiltransferaza (EC 2.1.1.264, rlmK (gen), 23S rRNK m7G2069 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanin2069-N7)-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin2069 u 23S rRNK S-adenozil-L-homocistein + N7-metilguanin2069 u 23S rRNK
Ovaj enzim specifično metiliše guanin2069 u poziciji N7 unutar 23S rRNK. U gama-proteobakterijama enzim takođe deluje kao EC 2.1.1.173, 23S rRNK (guanin2445-N2)-metiltransferaza, dok u beta-proteobakterijama tu aktivnost ima zasebni enzim.
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.