23S rRNK (adenozin1067-2'-O)-metiltransferaza
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| 23S rRNK (adenozin1067-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.230 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK (adenozin1067-2'-O)-metiltransferaza (EC 2.1.1.230, 23S rRNK A1067 2'-metiltransferaza, metilaza tiostreptonske otpornosti, metiltransferaza nosiheptidne otrpornosti) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (adenozin1067-2'-O)-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + adenozin1067 u 23S rRNK S-adenozil-L-homocistein + 2'-O-metiladenozin1067 u 23S rRNK
Ova metilaza je odgovorna za autoimunost Streptomyces azureus koji formira tiostrepton.
Reference[uredi | uredi kod]
- ↑ Bechthold, A. and Floss, H.G. (1994). „Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2′-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA”. Eur. J. Biochem. 224: 431-437. PMID 7925357.
- ↑ Thompson, J., Schmidt, F. and Cundliffe, E. (1982). „Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton”. J. Biol. Chem. 257: 7915-7917. PMID 6806287.
- ↑ Thompson, J. and Cundliffe, E. (1981). „Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton”. J. Gen. Microbiol. 124: 291-297.
- ↑ Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D., Murchie, A.I. and Xu, Y. (2010). „Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus”. Biochemistry 49: 6440-6450. PMID 20550164.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.