2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza

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2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza
Identifikatori
EC broj 3.7.1.14
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

2-Hidroksi-6-oksonona-2,4-diendioatna hidrolaza (EC 3.7.1.14, mhpC (gen)) je enzim sa sistematskim imenom (2Z,4E)-2-hidroksi-6-oksona-2,4-dienedioat sukcinilhidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) (2Z,4E)-2-hidroksi-6-oksonona-2,4-dien-1,9-dioat + H2O (2Z)-2-hidroksipenta-2,4-dienoat + sukcinat
(2) (2Z,4E,7E)-2-hidroksi-6-oksonona-2,4,7-trien-1,9-dioat + H2O (2Z)-2-hidroksipenta-2,4-dienoat + fumarat

Ovaj enzim katalizuje jedan od koraka u degradaciji fenilpropanoidnih jedinjenja.

Reference[uredi - уреди | uredi izvor]

  1. Burlingame, R. and Chapman, P.J. (1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155: 113–121. PMID 6345502. 
  2. Burlingame, R.P., Wyman, L. and Chapman, P.J. (1986). "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". J. Bacteriol. 168: 55–64. PMID 3531186. 
  3. Lam, W. W. Y and Bugg, T. D. H. (1994). "Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage". J. Chem. Soc., Chem. Commun. 10: 1163–1164. 
  4. Lam, W.W. and Bugg, T.D. (1997). "Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase". Biochemistry 36: 12242–12251. PMID 9315862. 
  5. Ferrández, A., García, J.L. and Díaz, E. (1997). "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". J. Bacteriol. 179: 2573–2581. PMID 9098055. 
  6. Díaz, E., Ferrández, A. and García, J.L. (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180: 2915–2923. PMID 9603882. 

Literatura[uredi - уреди | uredi izvor]

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