2,4-Dienoil-KoA reduktaza (NADPH)
(Preusmjereno sa stranice 2,4-dienoil-KoA reduktaza (NADPH))
| 2,4-dienoil-KoA reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 1.3.1.34 | ||||||||
| CAS broj | 82869-38-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2,4-dienoil-KoA reduktaza (NADPH) (EC 1.3.1.34, 4-enoil-KoA reduktaza (NADPH), 4-enoil koenzim A (redukovani nikotinamid adenin dinukleotid fosfat) reduktaza, 4-enoil-KoA reduktaza) je enzim sa sistematskim imenom trans-2,3-didehidroacil-KoA:NADP+ 4-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- trans-2,3-didehidroacil-KoA + NADP+ trans,trans-2,3,4,5-tetradehidroacil-KoA + NADPH + H+
Najbolji supstrati ove redukcije sadrže 2,4-diensku strukturu i imaju lanac dug 8 ili 10 ugljenika.
Reference[uredi | uredi kod]
- ↑ Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. (1982). „Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli”. Eur. J. Biochem. 125: 335-341. PMID 6749495.
- ↑ Kunau, W.-H. and Dommes, P. (1978). „Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria”. Eur. J. Biochem. 91: 533-544. PMID 729581.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.