2,4,6-Tribromofenol

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2,4,6-Tribromofenol
2,4,6-Tribromophenol.png
2,4,6-Tribromophenol-3D-balls.png
IUPAC ime
Drugi nazivi Tribromofenol; 2,4,6-TBP; TBP
Identifikacija
CAS registarski broj 118-79-6 YesY
PubChem[1][2] 1483
ChemSpider[3] 1438 YesY
DrugBank DB02417
KEGG[4] C14454
ChEBI 47696
ChEMBL[5] CHEMBL220087 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C6H3Br3O
Molarna masa 330.8 g mol−1
Agregatno stanje Bele igle ili prizme[6]
Tačka topljenja

95.5 °C[6]

Tačka ključanja

244 °C[7]
286 °C[6]

Rastvorljivost u vodi Malo rastvoran[6]
59-61 mg/L[8]
Opasnost
LD50 2000 mg/kg (pacov, oralno)[6]

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

2,4,6-Tribromofenol (TBP) je brominisani derivat fenola. On se koristi kao fungicid, prezervativ drveta, i kao intermedijer u pripremi sredstava za gašenje požara.

Produkcija[uredi - уреди | uredi izvor]

Mada je prirodni TBP identifikovan u okeanskim sedimentima kao metabolit morske faune,[9] komercijalni produkt se priprema veštačkim putem. Po procenama iz 2001. svetska proizvodnja nadmašuje 9.500 tona godišnje.[8] TBP se može pripremiti kontrolisanom reakcijom elementrnog broma i fenola:[7]

2,4,6-tribromophenol synthesis.PNG

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. 6,0 6,1 6,2 6,3 6,4 "3851: Tribromophenol" in Gardner's Commercially Important Chemicals: Synonyms, Trade Names, and Properties, G. W. A. Milne (Editor), ISBN 978-0-471-73518-2, page 632
  7. 7,0 7,1 Merck Index, 11th Edition, 9526
  8. 8,0 8,1 Concise International Chemical Assessment Document 66: 2,4,6-Tribromophenol and Other Simple Brominated Phenols, International Programme on Chemical Safety
  9. Fielman KT, Woodin SA, Lincoln DE (2001). "Polychaete indicator species as a source of natural halogenated organic compounds in marine sediments". Environmental Toxicology and Chemistry 20 (4): 738–747. PMID 11345448. doi:10.1002/etc.5620200407.